Acute Lymphoblastic Leukaemia Committee (ALL)

Abstract

The IBFM ALL Committee is a network that shares published and unpublished basic science and clinical trials data from AIEOP/BFM, ALLTogether, ALL-IC, Australian, and Japanese collaborators to promote the development of more effective and less toxic treatment strategies for childhood acute lymphoblastic leukemia (ALL). The committee and its members collaborate closely with US groups (The Children’s Oncology Group, St Jude Children’s Research Hospital, and the Dana Farber Consortium), including within the so-called Ponte di Legno consortium (PdL)) that share data on rare ALL subsets for the development of future clinical trials.

Committee members participate in organizing interim ALL meetings in Milan (January, annually), SIOPE meetings (annually), PdL meetings (at 1-2 years intervals), and in-between online meetings.

The committee chair is member of the IBFM Board, and the committee works closely with the other IBFM committees to promote research, meetings, and educational activities.

• AIEOP-BFM ALL 2017 (2017 – )

  Randomized clinical trial for ALL (age 1-18y)

• ALL-IC 2022 (3/2023 – )

  Randomized clinical trial for ALL in countries with limited resources

• ALLTogether-1 (2021 – )

  Randomized clinical trial for ALL (age up to 45 years)

• EsPhALL2017-COGAALL1631

  Randomized trial for patients with Ph+ ALLAIEOP-BFM ALL 2017 (2017-2023): Randomized clinical trial (age 1.0-21.9y)

• Interfant-21 (2/2023 – )

  Non-randomized clinical trial for all pts under 1y of age with KMT2A rear. ALL

• AIEOP-BFM ALL 2000 (2000-2006)

  Randomized clinical trial for ALL (age 1-18y)

• AIEOP-BFM ALL 2009

  Randomized clinical trial for ALL (age 1-18y)

• ALL IC-BFM 2009 (2010-2018)

  Randomized clinical trial for ALL in countries with limited resources

• ALL-SCT BFM 2003

  HSCT in VHR ALL

• ALLIC-BFM 2002 (2002-2009)

  Randomized clinical protocol for ALL in countries with limited resources

• EsPhALL (2004-2009)

  ALL positive for the t(9;22)[BCR/ABL] translocation

• IDH (1991-1995)

  SR ALL

• INTERFANT-06

  Randomized clinical trial for ALL under 1y

• Interfant-99 (1999-2006)

  ALL below the age of one year (ALL<1y)

• VCR/Steroid Pulses (1995-2000)

  MR ALL

• hSCT in VHR ALL (1995-2000)

Selected publications