Stem Cell Transplantation Committee (SCT)

Abstract

Our sub-committee is dedicated to every aspect of stem cell transplantation in any malignant diseases: from indication to late effect through conditioning regimen, donor and stem cell source selection, GvHD prophylaxis and treatment or supportive care.

We invite any colleagues interested in SCT to participate to our both retrospective and prospective studies, as well as to propose projects and/or report their own work. We want to be very inclusive and young colleagues are very welcome.

One of our main achievement of the last 15 years is the IBFM-ALL study program from BFM-ALL-SCT 2003 to FORUM. Then, our most exciting perspective is to work collectively on the next international prospective study about SCT in high-risk ALL in pediatric patients. Nevertheless, other topics and other diseases (AML, NHL, JMML) have to be actively discussed as well.

Open and completed clinical trials

Open

ALL SCT PED 2012 Forum (for omitting radiation under majority age). Allogeneic Stem Cell Transplantation in Children and Adolescents with ALL in CR. Prospective controlled randomized international study

Principal investigator: Christina Peters, E-Mail: peters@stanna.at

Participating countries: Austria, Argentina, Australia, Chile, Czech Republic. Denmark, Finland, France, Germany, Greece, Hong-Kong, Hungary, Japan, Israel, Italy, The Netherlands, New Zealand, Norway, Polland, Slovakia, Sweden, Spain, Switzerland, Turkey, United Kingdom, USA

The study is open for international recruitment. Randomization is closed

Completed

ALL SCT BFM International, Allogeneic Stem Cell Transplantation for Children and Adolescents with ALL, Prospective international controlled comparative non-randomized study

Principal investigator: Christina Peters, E-Mail: peters@stanna.at

Start: January 2007

Participating countries: Austria, Chile, Czech Republic, Denmark, France, Israel, Italy, The Netherlands, Poland, Slowakia, Sweden, Turkey

Role of MRD in ALL after SCT: Retrospective observational multi-center WIG joint I-BFM/EBMT and COG/PBMTC study for assessing the role of post-transplant MRD in children with ALL

Main investigators: Peter Bader & Michael Pulsipher, E-Mail: bader@kgu.de, mpulsipher@chla.usc.edu

Active countries: Australia, Austria, Germany, Italy, The Netherlands, Switzerland, United States of America

AML post transplant relapse. A retrospective I-BFM study

Main investigators: Martin Sauer, E-Mail: martin@mh-hannover.de

Active countries: Australia, Denmark, Italy, Netherlands, Belgium, Israel, Sweden, Norway, Finland, Austria, Czech Republic, Germany. Accrual: 289 patients (175 non-transplanted, 105 transplanted)

AML eligibility criteria for transplantation: an I-BFM Survey. Survey circulated among SCT Committee Members regarding SCT eligibility criteria in AML pediatric patients

Main investigator: Brenda Gibson, E-Mail: Gibson@ggc.scot.nhs.uk

Participating groups: AIEOP, BFM, Canada, COG, CPH, DCOG, France, Gazi, Israel, JCCG / JPLSG, NOPHO, PINDA, PLLSG, Serbia, Slovenia, St.Jude, UK. Accrual: 18 countries

CML SCT I-BFM: Multicenter Study: Prospective controlled multi-center therapy optimization study for children with CML undergoing SCT. Prospective international single-arm study

Main investigator: Susanne Matthes-Martin, E-Mail: matthes@stanna.at

Active countries: Austria, Czech Republic, Germany, Israel, Italy, Poland. Accrual: 13 enrolled patients, + 12 observational patients. Outcome on 25 patients: alive 24/25, deaths in CR 1/25, TKI-free alive 22/25. Closure planned in 2017.

The study is open for international recruitment since 2009

Refractory NHL management within I-BFM. A retrospective I-BFM study

Main investigators: Birgit Burkhardt, E-Mail: burkhardt@ukmuenster.de

Active countries: Australia, Austria, Belarus, Czech Republic, France, Finland, Germany, Hong-Kong, Italy, The Netherlands, Poland, Russia, Slovakia, Switzerland, Turkey, United Kingdom, United States of America. Accrual: 514 patients

Status: Analyses ongoing.

Selected publications

Committee Members