Committee chairs

Fréderic Millot (CML)
Fréderic Millot Poitiers University Hospital, France
Markus Metzler (CML)
Markus Metzler University Hospital Erlangen, Germany

Abstract

The Mission of the Chronic Myeloid Leukemia group is to improve treatments for children and adolescents with chronic myeloid leukemia.

Our objectives are:

  • To facilitate the development of interventional clinical studies and standards in children with CML including all relevant treatment modalities
  • To facilitate registries to promote continuity over successive trials
  • To facilitate the development of basic and translational research projects in children with hematological malignancies that help to define the therapeutic strategies in patients with CML
  • Identify and mentor next generation clinical scientists in the field of myeloproliferative diseases

Scientific aims

  • Comparison of clinical and molecular signatures in Pediatric and Adult CML
  • Differentiating CML-BP from CML-like ALL
  • Identify predictive markers for successful TFR, dose reduction and stopping TKI
  • Study the genetic predisposition in CML
  • Understand the mechanism of the influence of TKI on bone growth

Open and completed clinical trials

International CML registry

Management of children and adolescents with chronic myeloid leukemia in blast phase: International pediatric CML expert panel recommendations.

  • Asciminib CABL001I12201 – ASC4KIDS

  • Bosutinib Study ITCC-054/AAML1921

  • Ponatinib Paediatric INCB84344-102 Study

Selected publications (last 5 years)

1
Management of children and adolescents with chronic myeloid leukemia in blast phase: International pediatric CML expert panel recommendations
2023 Mar;37(3):505-517. doi: 10.1038/s41375-023-01822-2. Epub 2023 Jan 27.
Leukemia
Sembill S, Ampatzidou M, Chaudhury S, Dworzak M, Kalwak K, Karow A, Kiani A, Krumbholz M, Luesink M, Naumann-Bartsch N, De Moerloose B, Osborn M, Schultz KR, Sedlacek P, Giona F, Zwaan CM, Shimada H, Versluijs B, Millot F, Hijiya N, Suttorp M, Metzler M.
2
Recent progress in the management of pediatric chronic myeloid leukemia
2023 Feb;117(2):182-187. doi: 10.1007/s12185-022-03526-2. Epub 2022 Dec 27.
Int J Hematol
Haruko Shima, Hiroyuki Shimada
3
Impact of BCR::ABL1 transcript type on RT-qPCR amplification performance and molecular response to therapy
2022 Jul;36(7):1879-1886. doi: 10.1038/s41375-022-01612-2. Epub 2022 Jun 8.
Leukemia
Matthew Salmon, Helen E White, Hana Zizkova, Andrea Gottschalk, Eliska Motlova, Nuno Cerveira, Dolors Colomer, Daniel Coriu, Georg N Franke, Enrico Gottardi, Barbara Izzo, Tomas Jurcek, Thomas Lion, Vivien Schäfer, Claudia Venturi, Paolo Vigneri, Magdalena Zawada, Jan Zuna, Lenka Hovorkova, Jitka Koblihova, Hana Klamova, Marketa Stastna Markova, Dana Srbova, Adela Benesova, Vaclava Polivkova, Daniela Zackova, Jiri Mayer, Ingo Roeder, Ingmar Glauche, Thomas Ernst, Andreas Hochhaus, Katerina Machova Polakova, Nicholas C P Cross
4
Outcome prediction of chronic myeloid leukemia (CML) in children
2022 Aug;101(8):1677-1688. doi: 10.1007/s00277-022-04852-5. Epub 2022 Jun 1.
Ann Hematol
Wing-Yan Leung, Daniel Ka-Leung Cheuk, Frankie Wai-Tsoi Cheng, Alex Wing-Kwan Leung, Ka-Ho Chiu, Karin Kar-Huen Ho, Chak-Ho Li, Godfrey Chi-Fung Chan
5
Standardization of molecular monitoring of CML: results and recommendations from the European treatment and outcome study
2022 Jul;36(7):1834-1842. doi: 10.1038/s41375-022-01607-z. Epub 2022 May 25.
Leukemia
Helen E White, Matthew Salmon, Francesco Albano, Christina Søs Auður Andersen, Stefan Balabanov, Gueorgui Balatzenko, Gisela Barbany, Jean-Michel Cayuela, Nuno Cerveira, Pascale Cochaux, Dolors Colomer, Daniel Coriu, Joana Diamond, Christian Dietz, Stéphanie Dulucq, Marie Engvall, Georg N Franke, Egle Gineikiene-Valentine, Michal Gniot, María Teresa Gómez-Casares, Enrico Gottardi, Chloe Hayden, Sandrine Hayette, Andreas Hedblom, Anca Ilea, Barbara Izzo, Antonio Jiménez-Velasco, Tomas Jurcek, Veli Kairisto, Stephen E Langabeer, Thomas Lion, Nora Meggyesi, Semir Mešanović, Luboslav Mihok, Gerlinde Mitterbauer-Hohendanner, Sylvia Moeckel, Nicole Naumann, Olivier Nibourel, Elisabeth Oppliger Leibundgut, Panayiotis Panayiotidis, Helena Podgornik, Christiane Pott, Inmaculada Rapado, Susan J Rose, Vivien Schäfer, Tasoula Touloumenidou, Christopher Veigaard, Bianca Venniker-Punt, Claudia Venturi, Paolo Vigneri, Ingvild Vorkinn, Elizabeth Wilkinson, Renata Zadro, Magdalena Zawada, Hana Zizkova, Martin C Müller, Susanne Saussele, Thomas Ernst, Katerina Machova Polakova, Andreas Hochhaus, Nicholas C P Cross
6
Prognostic Factors for Outcomes of Allogeneic HSCT for Children and Adolescents/Young Adults With CML in the TKI Era
2022 Jul;28(7):376-389. doi: 10.1016/j.jtct.2022.04.011. Epub 2022 Apr 18.
Transplant Cell Ther
Hiroyuki Shimada, Akihiko Tanizawa, Takeshi Kondo, Tokiko Nagamura-Inoue, Masahiro Yasui, Arinobu Tojo, Hideki Muramatsu, Tetsuya Eto, Noriko Doki, Masatsugu Tanaka, Maho Sato, Maiko Noguchi, Naoyuki Uchida, Yoshiyuki Takahashi, Naoki Sakata, Tatsuo Ichinohe, Yoshiko Hashii, Koji Kato, Yoshiko Atsuta, Kazuteru Ohashi; Pediatric and Adult CML/MPN Working Groups of the Japanese Society for Transplantation and Cellular Therapy
7
Discontinuation of tyrosine kinase inhibitors in pediatric chronic myeloid leukemia
2022 Aug;69(8):e29699. doi: 10.1002/pbc.29699. Epub 2022 Apr 11.
Pediatr Blood Cancer
Haruko Shima, Akiko Kada, Akihiko Tanizawa, Iori Sato, Chikako Tono, Masaki Ito, Yuki Yuza, Akihiro Watanabe, Kiyoko Kamibeppu, Hideko Uryu, Katsuyoshi Koh, Chihaya Imai, Nao Yoshida, Yuhki Koga, Naoto Fujita, Akiko M Saito, Souichi Adachi, Eiichi Ishii, Hiroyuki Shimada
8
Comparison of the Transcriptomic Signatures in Pediatric and Adult CML
2021 Dec 14;13(24):6263. doi: 10.3390/cancers13246263.
Cancers (Basel)
Minyoung Youn, Stephanie M Smith, Alex Gia Lee, Hee-Don Chae, Elizabeth Spiteri, Jason Erdmann, Ilana Galperin, Lara Murphy Jones, Michele Donato, Parveen Abidi, Henrique Bittencourt, Norman Lacayo, Gary Dahl, Catherine Aftandilian, Kara L Davis, Jairo A Matthews, Steven M Kornblau, Min Huang, Nathan Sumarsono, Michele S Redell, Cecilia H Fu, I-Ming Chen, Todd A Alonzo, Elizabeth Eklund, Jason Gotlib, Purvesh Khatri, E Alejandro Sweet-Cordero, Nobuko Hijiya, Kathleen M Sakamoto
9
Asciminib and ponatinib exert synergistic anti-neoplastic effects on CML cells expressing BCR-ABL1 T315I-compound mutations
2021 Sep 15;11(9):4470-4484. eCollection 2021.
Am J Cancer Res
Karoline V Gleixner, Yüksel Filik, Daniela Berger, Christina Schewzik, Gabriele Stefanzl, Irina Sadovnik, Lina Degenfeld-Schonburg, Gregor Eisenwort, Mathias Schneeweiss-Gleixner, Konstantin Byrgazov, Wolfgang R Sperr, Jiří Mayer, Thomas Lion, Peter Valent
10
Discontinuation of Imatinib in Children with Chronic Myeloid Leukemia: A Study from the International Registry of Childhood CML
2021 Aug 15;13(16):4102. doi: 10.3390/cancers13164102.
Cancers (Basel)
Frédéric Millot, Meinolf Suttorp, Stéphanie Ragot, Guy Leverger, Jean-Hugues Dalle, Caroline Thomas, Nathalie Cheikh, Brigitte Nelken, Marilyne Poirée, Geneviève Plat, Birgitta Versluys, Birgitte Lausen, Marina Borisevich
11
Illuminating novel biological aspects and potential new therapeutic approaches for chronic myeloproliferative malignancies
2020 Dec;38(5):654-664. doi: 10.1002/hon.2771. Epub 2020 Sep 4.
Hematol Oncol
Tariq I Mughal, Naveen Pemmaraju, Bethan Psaila, Jerald Radich, Prithviraj Bose, Thomas Lion, Jean-Jacques Kiladjian, Raajit Rampal, Tania Jain, Srdnan Verstovsek, Abdulraheem Yacoub, Jorge E Cortes, Ruben Mesa, Giuseppe Saglio, Richard A van Etten
12
A phase 1 study to evaluate the feasibility and efficacy of the addition of ropeginterferon alpha-2b to imatinib treatment in patients with chronic phase chronic myeloid leukemia (CML) not achieving a deep molecular response (molecular remission 4.5)-AGMT_CML 1
2020 Dec;38(5):792-798. doi: 10.1002/hon.2786. Epub 2020 Aug 19.
Hematol Oncol
Sonja Heibl, Veronika Buxhofer-Ausch, Stefan Schmidt, Gerald Webersinke, Thomas Lion, Gudrun Piringer, Thomas Kuehr, Dominik Wolf, Thomas Melchardt, Richard Greil, Josef Thaler
13
Imatinib in the treatment of chronic myeloid leukemia in children and adolescents is effective and well tolerated: Report of the Polish Pediatric Study Group for the Treatment of Leukemias and Lymphomas
2018 Jan;27(1):91-98. doi: 10.17219/acem/66462.
Adv Clin Exp Med
Małgorzata Janeczko-Czarnecka, Maryna Krawczuk-Rybak, Irena Karpińska-Derda, Maciej Niedźwiecki, Katarzyna Musioł, Magdalena Ćwiklińska, Katarzyna Drabko, Katarzyna Mycko, Tomasz Ociepa, Katarzyna Pawelec, Danuta Januszkiewicz-Lewandowska, Marek Ussowicz, Blanka Rybka, Renata Ryczan-Krawczyk, Andrzej Kołtan, Grażyna Karolczyk, Agnieszka Zaucha-Prażmo, Wanda Badowska, Krzysztof Kałwak