Committee Chair

Andishe Attarbaschi (NHL)
Andishe Attarbaschi St. Anna Kinderspital, Vienna

Abstract

Children develop a rather different spectrum of non-Hodgkin’s lymphoma (NHL) than adults, consisting largely of mature B-cell-derived malignancies (Burkitt’s lymphoma & leukemia, diffuse large B-cell lymphoma, and primary mediastinal large B-cell lymphoma), but also anaplastic large cell lymphomas, and immature malignancies derived from both cell types (T- or B-cell lymphoblastic lymphoma). Other, rarer NHL entities are also seen and include pediatric-type follicular lymphoma, pediatric nodal marginal zone lymphoma, primary central nervous system lymphomas, and non-anaplastic peripheral T-cell lymphomas. In general, NHL diagnosed in children and adolescents has a good prognosis with over 90% of children being cured, although treatment remains a combination of cytotoxic agents with significant side-effects, and children that relapse largely have a poor prognosis. With the advent of prognostic biomarkers and a deeper understanding of the biology of this class of malignancies, novel treatment approaches are being tested in collaborative trials with the hope that they will improve the outlook for children, adolescents and young adults with NHL.

Scientific aims

  • Enhancement of diagnostics and therapy of children and AYAs with NHL
  • Assessment of outcomes and prognosis of children and AYAs with NHL
  • Diagnostic and therapy guidelines for rare NHL entities
  • Pre-existing disorders and risk of the development of NHL
  • Cooperation with other societies (i.e., EICNHL, other i-BFM Committees, and SIOPE)

Ongoing clinical trials

  • EICNHL trial

    ALCL-VBL study in SR ALK-pos. ALCL

  • EICNHL/i-BFM trial

    LBL 2018 study in lymphoblastic lymphoma

  • NHL-BFM and NOPHO trial

    B-NHL 2013 study in mature B-cell neoplasms

Selected publications

1
Molecular characterization and clinical outcome of B-cell precursor acute lymphoblastic leukemia with IG-MYC rearrangement
2023 Mar 1;108(3):717-731. doi: 10.3324/haematol.2021.280557.
Haematologica
Simon Bomken, Amir Enshaei, Edward C Schwalbe, Aneta Mikulasova, Yunfeng Dai, Masood Zaka, Kent T M Fung, Matthew Bashton, Huezin Lim, Lisa Jones, Nefeli Karataraki, Emily Winterman, Cody Ashby, Andishe Attarbaschi, Yves Bertrand, Jutta Bradtke, Barbara Buldini, G A Amos Burke, Giovanni Cazzaniga, Gudrun Gohring, Hesta A De Groot-Kruseman, Claudia Haferlach, Luca Lo Nigro, Mayur Parihar, Adriana Plesa, Emma Seaford, Edwin Sonneveld, Sabine Strehl, Vincent H J Van der Velden, Vikki Rand, Stephen P Hunger, Christine J Harrison, Chris M Bacon, Frederik W Van Delft, Mignon L Loh, John Moppett, Josef Vormoor, Brian A Walker, Anthony V Moorman, Lisa J Russell
2
Pediatric Precursor B-Cell Lymphoblastic Malignancies: From Extramedullary to Medullary Involvement
2022 Aug 12;14(16):3895. doi: 10.3390/cancers14163895.
Cancers (Basel)
Emma Kroeze, Laura Arias Padilla, Max Bakker, Judith M Boer, Melanie M Hagleitner, Birgit Burkhardt, Takeshi Mori, Andishe Attarbaschi, Jaime Verdú-Amorós, Marta Pillon, Liliya Anderzhanova, Edita Kabíčková, Alan K S Chiang, Rejin Kebudi, Karin Mellgren, Jelena Lazic, Janez Jazbec, Jules P P Meijerink, Auke Beishuizen, Jan L C Loeffen
3
Consensus Recommendations for the Clinical Management of Hematological Malignancies in Patients with DNA Double Stranded Break Disorders
2022 Apr 14;14(8):2000. doi: 10.3390/cancers14082000.
Cancers (Basel)
Agata Pastorczak, Andishe Attarbaschi, Simon Bomken, Arndt Borkhardt, Jutte van der Werff Ten Bosch, Sarah Elitzur, Andrew R Gennery, Eva Hlavackova, Arpád Kerekes, Zdenka Křenová, Wojciech Mlynarski, Tomasz Szczepanski, Tessa Wassenberg, Jan Loeffen
4
Second malignancies after treatment of childhood non-Hodgkin lymphoma: a report of the Berlin-Frankfurt-Muenster study group
2021 May 1;106(5):1390-1400. doi: 10.3324/haematol.2019.244780.
Haematologica
Olga Moser, Martin Zimmermann, Ulrike Meyer, Wolfram Klapper, Ilske Oschlies, Martin Schrappe, Andishe Attarbaschi, Georg Mann, Felix Niggli, Claudia Spix, Udo Kontny, Thomas Klingebiel, Alfred Reiter, Birgit Burkhardt, Wilhelm Woessmann
5
Treatment and Outcome Analysis of 639 Relapsed Non-Hodgkin Lymphomas in Children and Adolescents and Resulting Treatment Recommendations
2021 Apr 25;13(9):2075. doi: 10.3390/cancers13092075.
Cancers (Basel)
Andishe Attarbaschi, Auke Beishuizen, Adriana Balduzzi, Jochen Buechner, Birgit Burkhardt, Eva Bubanska, Alan Kwok Shing Chiang, Monika Csoka, Svetlana Donska, Alina Fedorova, Nathalie Garnier, Volkan Hazar, Heidi Herbrueggen, Lisa Lyngsie Hjalgrim, Edita Kabickova, Jelena Lazic, Jan Loeffen, Kristin Koeppen, Gergely Krivan, Julia Palma, Anna Pieczonka, Marta Pillon, Natalia Myakova, Veronique Minard-Colin, Stephanie Mueller, Karin Mellgren, Felix Niggli, Tomoo Osumi, Anne Uyttebroeck, Jaime Verdu-Amoros, Wilhelm Woessmann, Martin Zimmermann, Mary Taj, Jacek Wachowiak, G A Amos Burke, Mara Andres, Andishe Attarbaschi, Wilhelm Woessmann
6
Primary post-transplant lymphoproliferative disorder of the central nervous system: characteristics, management and outcome in 25 paediatric patients
2021 Jun;193(6):1178-1184. doi: 10.1111/bjh.17398. Epub 2021 Mar 25.
Br J Haematol
Andishe Attarbaschi, Simon Bomken, Birgit Burkhardt, Alan K S Chiang, Monika Csoka, Anna Füreder, Stéphanie Haouy, Jelena Lazic, Rebecca Ling, Britta Maecker-Kolhoff, Natalia Miakova, Veronique Minard-Colin, Mary M Taj, Suzanne D Turner, Anne Uyttebroeck
7
Rare non-Hodgkin lymphoma of childhood and adolescence: A consensus diagnostic and therapeutic approach to pediatric-type follicular lymphoma, marginal zone lymphoma, and nonanaplastic peripheral T-cell lymphoma
2020 Aug;67(8):e28416. doi: 10.1002/pbc.28416. Epub 2020 May 26.
Pediatr Blood Cancer
Andishe Attarbaschi, Oussama Abla, Laura Arias Padilla, Auke Beishuizen, G A Amos Burke, Laurence Brugières, Julie Bruneau, Birgit Burkhardt, Emanuele S G d'Amore, Wolfram Klapper, Udo Kontny, Karin Mellgren, Marta Pillon, Mary Taj, Suzanne D Turner, Anne Uyttebroeck, Wilhelm Woessmann
8
Primary central nervous system lymphoma: initial features, outcome, and late effects in 75 children and adolescents
2019 Dec 23;3(24):4291-4297. doi: 10.1182/bloodadvances.2019001062.
Blood Adv
Andishe Attarbaschi, Oussama Abla, Leila Ronceray, Shweta Bansil, Simon Bomken, Birgit Burkhardt, Francesco Ceppi, Alan K S Chiang, Hema Dave, Alina Fedorova, Michael Henry, Janez Jazbec, Edita Kabickova, Rishi S Kotecha, Jelena Lazic, Jan Loeffen, Natalia Miakova, Tomoo Osumi, Marta Pillon, Apostolos Pourtsidis, Charlotte Rigaud, Gevorg Tamamyan, Sneha Tandon, Anne Uyttebroeck, Jamie Verdu-Amoros, Wilhelm Woessmann, Grazyna Wrobel, Lisa Giulino-Roth
9
Non-Hodgkin's Lymphoma in Childhood and Adolescence
ISBN 3030117693, 9783030117696
Springer
Andishe Attarbaschi, Oussama Abla
10
Current Understanding and Future Research Priorities in Malignancy Associated With Inborn Errors of Immunity and DNA Repair Disorders: The Perspective of an Interdisciplinary Working Group
2018 Dec 12:9:2912. doi: 10.3389/fimmu.2018.02912. eCollection 2018.
Front Immunol
Simon Bomken, Jutte van der Werff Ten Bosch, Andishe Attarbaschi, Chris M Bacon, Arndt Borkhardt, Kaan Boztug, Ute Fischer, Fabian Hauck, Roland P Kuiper, Tim Lammens, Jan Loeffen, Bénédicte Neven, Qiang Pan-Hammarström, Isabella Quinti, Markus G Seidel, Klaus Warnatz, Claudia Wehr, Arjan C Lankester, Andrew R Gennery
11
Children and adolescents with marginal zone lymphoma have an excellent prognosis with limited chemotherapy or a watch-and-wait strategy after complete resection
2018 Apr;65(4). doi: 10.1002/pbc.26932. Epub 2017 Dec 29.
Pediatr Blood Cancer
Leila Ronceray, Oussama Abla, Shlomit Barzilai-Birenboim, Simon Bomken, Alan Ks Chiang, Janez Jazbec, Edita Kabickova, Jelena Lazic, Auke Beishuizen, Karin Mellgren, Fumiko Tanaka, Marta Pillon, Christine Devalck, Marina Gouttenoire, Olga Makarova, Birgit Burkhardt, Andishe Attarbaschi; European Intergroup for Childhood Non-Hodgkin Lymphoma (EICNHL) and the International Berlin-Frankfurt-Münster (i-BFM) Study Group
12
Non-Hodgkin lymphoma and pre-existing conditions: spectrum, clinical characteristics and outcome in 213 children and adolescents
2016 Dec;101(12):1581-1591. doi: 10.3324/haematol.2016.147116. Epub 2016 Aug 11.
Haematologica
Andishe Attarbaschi, Elisa Carraro, Oussama Abla, Shlomit Barzilai-Birenboim, Simon Bomken, Laurence Brugieres, Eva Bubanska, Birgit Burkhardt, Alan K S Chiang, Monika Csoka, Alina Fedorova, Janez Jazbec, Edita Kabickova, Zdenka Krenova, Jelena Lazic, Jan Loeffen, Georg Mann, Felix Niggli, Natalia Miakova, Tomoo Osumi, Leila Ronceray, Anne Uyttebroeck, Denise Williams, Wilhelm Woessmann, Grazyna Wrobel, Marta Pillon; European Intergroup for Childhood Non-Hodgkin Lymphoma (EICNHL) and the International Berlin-Frankfurt-Münster (i-BFM) Study Group
13
Non-anaplastic peripheral T cell lymphoma in children and adolescents-an international review of 143 cases
2016 Aug;95(8):1295-305. doi: 10.1007/s00277-016-2722-y. Epub 2016 Jun 7.
Ann Hematol
K Mellgren, A Attarbaschi, O Abla, S Alexander, S Bomken, E Bubanska, A Chiang, M Csóka, A Fedorova, E Kabickova, L Kapuscinska-Kemblowska, R Kobayashi, Z Krenova, F Meyer-Wentrup, N Miakova, M Pillon, G Plat, A Uyttebroeck, D Williams, G Wróbel, U Kontny; European Intergroup for Childhood Non-Hodgkin Lymphoma (EICNHL) and the international Berlin-Frankfurt-Münster (i-BFM) Group
14
Children and adolescents with follicular lymphoma have an excellent prognosis with either limited chemotherapy or with a "Watch and wait" strategy after complete resection
2013 Nov;92(11):1537-41. doi: 10.1007/s00277-013-1785-2. Epub 2013 May 12.
Ann Hematol
Andishe Attarbaschi, Auke Beishuizen, Georg Mann, Angelo Rosolen, Tetsuya Mori, Anne Uyttebroeck, Felix Niggli, Monika Csoka, Zdenka Krenova, Karin Mellgren, Edita Kabickova, Alan Ks Chiang, Alfred Reiter, Denise Williams, Birgit Burkhardt; European Intergroup for Childhood Non-Hodgkin Lymphoma (EICNHL) and the international Berlin-Frankfurt-Münster (i-BFM) Study Group